Fight of Opposite Styles: Liverpool Vs. Atletico Betting Predictions & Winning Tips (UEFA Champions League 2025/26 League Phase, September 17)

Liverpool returns to Champions League action on Wednesday with a home clash against Atletico Madrid at Anfield. The Reds entered the international break with a flawless league record, while Atletico has managed just one win from four domestic fixtures this season. Can Simeone’s side secure a second victory in this opening group-stage encounter? Our Liverpool vs Atletico predictions guide offers a preview of what to expect on Wednesday.
Key Info: Liverpool vs Atletico UCL 2025-26 League Phase Match
LIV vs ATM: Time, Date & Venue
Liverpool led the league phase of the UCL last season but were eliminated from the round of 16 by eventual champions PSG. Can they get on to a perfect start at Anfield?
ℹ️ Tournament: | UEFA Champions League season 2025-26, League Stage (Round 1) |
⚽️ Venue: | Anfield Stadium, Liverpool, England |
🗓️ Date: | 17 September 2025 |
⏰ Time: | 19:00 GMT on Wednesday |
Liverpool vs Atletico Odds
Unsurprisingly, popular bookies for football are favoring Liverpool to get a home win at odds of 1.62 (2/3). Given their poor start to the season, Atletico is the underdog with odds of 5.00 (4/1). Liverpool vs Atletico odds for a draw stand at 3.70 (8/3).
Liverpool – Atletico: H2H
In their last five matchups, both teams have been evenly matched, with two wins apiece and a single draw.
- Liverpool 2-0 Atletico (3 November 2021)
- Atletico 2-3 Liverpool (19 October 2021)
- Liverpool 2-3 Atletico (11 March 2020)
- Atletico 1-0 Liverpool (18 February 2020)
- Atletico 1-1 Liverpool (2 August 2017)
Betting Preview: Latest Results and Roster Updates
Liverpool FC
Liverpool has struggled in Europe since reaching the Champions League final in 2022. Last season, they suffered their second consecutive last-16 elimination despite strong domestic performances in the Premier League. The Reds finished first in the UCL league phase last season with seven wins from eight matches. However, Paris Saint-Germain knocked them out in the last 16 on penalties. This season, UCL League Phase bookies have positioned the Reds among the top favorites to secure automatic qualifications once again.
Arne Slot’s side has signaled intent this season with the high-profile additions of Florian Wirtz, Hugo Ekitike, and Alexander Isak. With greater attacking creativity, the Reds will look to mount a serious push for European success. Domestically, Liverpool’s perfect record has come with narrow margins, as late goals have decided all four league victories. Their most recent win was sealed by a 95th-minute penalty from Mohamed Salah against Burnley.
Only Stefan Bajcetic is out due to a hamstring injury, but he is far from being a starting player.
- Last Five Games: WWWWL
Atlético de Madrid
Last season, Atletico Madrid reached the Champions League last 16 after finishing fifth in the league phase. They would then go on to lose to rivals Real Madrid on penalties in controversial circumstances. That outcome marked their second failure in three seasons to reach the quarter-finals.
Domestically, Los Colchoneros finished third in La Liga despite a poor start to their season. Simeone’s are repeating this same trend once again, with their only win so far coming against Villareal in their last league match. Atletico will look to build on that 2:0 victory by securing another win away at Anfield.
Baena joins Almada on the sidelines after muscle discomfort. Giménez also remains unavailable for Atlético Madrid.
- Last Five Games: WDDLW
Betting Predictions For Liverpool vs Atletico
We offer our Liverpool vs Atletico betting predictions in this section:
Liverpool To Win @ 1.62 (2/3)
1 (100%)
0
Liverpool approaches this clash in a far stronger position than Atletico Madrid. They have won four and lost once in their last five matches. That run includes a home victory against Arsenal. In contrast, Atletico have one win in four La Liga games, a sign of their struggle to establish rhythm this season. Anfield’s intimidating atmosphere further strengthens Liverpool’s prospects on European nights. The Reds have also managed two wins and one loss in their last three encounters against this opponent. With hundreds of UEFA Champions League betting odds available, a simple victory for Arne Slot’s men at 1.62 (2/3) looks among the most attractive.
Total Goals – Over 3.5 @ 2.62 (5/3)
0
(100%) 1
Liverpool’s recent outings have consistently produced high-scoring results, with three of their last five matches across all competitions featuring more than three goals. Their forward line continues to provide multiple scoring threats. History supports the trend as well, with two of their last three encounters against Atletico surpassing 3.5 goals. All signs point toward another goal-filled contest at Anfield.
Hugo Ekitike To Score Anytime @ 2.37 (4/3)
0
(100%) 1
Ekitike starred for Frankfurt last season, scoring fifteen Bundesliga and four European goals. The French forward has quickly impressed for Liverpool, scoring twice in three league appearances. His early form shows strong adaptation to both the Premier League and the club. Alongside Salah, Wirtz, and Gakpo, he benefits from excellent attacking support. These factors make Ekitike a strong candidate to score against Atletico with the odds of 2.37 (4/3).
Recommended Liverpool vs Atletico Betting Picks
Here are our Liverpool vs Atletico betting picks:
Those looking for attractive sports football odds should pay attention to this highly anticipated clash. Liverpool boasts a far superior form recently than Atletico, which could propel them to victory at Anfield. You can use our Liverpool vs Atletico betting tips to stake and win extra cash.
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