The pre-season is finally over, with the 25/26 NFL season starting next week. The Philadelphia Eagles finally took their revenge and beat the Kansas City Chiefs in Super Bowl 59, and they are coming into this season as the defending champions and one of the top favorites. There are a lot of interesting NFL moves in the off-season, so let’s take a look at each team’s chances.
The full 18-week NFL schedule for the 2025-26 season was released three months ago, as the pre-season games ended this week, and the regular season kicks off on September 4, 2025. The regular season ends on January 4, 2026, while the Super Bowl LX game will be played on February 8 at Levi’s Stadium (San Francisco 49ers’ stadium) in Santa Clara, California. The opening matchup will be between the defending champions, the Philadelphia Eagles, and their NFC East Division rivals, the Dallas Cowboys.
Here are our looks and analyses for the top contenders to win the title this season, and we brought the Super Bowl 60 odds from the best betting sites for American football:
The 2025 NFL season odds show that this will be a very interesting season, as there are no clear favorites to win the title. The Baltimore Ravens last won the championship in 2012, but they now have the best team that they have had in a long time. The Buffalo Bills have been unlucky not to win a championship with this super team, led by Josh Allen, but this could be their year if they bring their best form.
The Philadelphia Eagles are the defending champions, and they don’t have any clear weaknesses right now, so they have a good chance of winning back-to-back titles. The Kansas City Chiefs have reached four of the last five Super Bowl games, and they won three of them. The Detroit Lions have never won a Super Bowl, but they have improved immensely in the last couple of years.
The usual 32 NFL teams will be competing for the championship this season, and they are split equally into the AFC and the NFC, with each conference containing four divisions of four teams. Each team plays a total of 17 games in the regular season, with the top team in each division qualifying directly for the playoffs, while the following top three teams in each conference take the remaining spots.
The top team from each conference receives a bye from the Wild Card Round, while the remaining 12 teams clash in single-elimination matches. The Divisional Round, the AFC and NFC Championship Games, and finally the Super Bowl come after that.
The NFL was founded in 1920 as the American Professional Football Conference, while the Super Bowl was first played in 1967, which the Green Bay Packers won. This will be the 106th NFL season and the 61st edition of the Super Bowl. There are 20 teams that managed to win at least one Super Bowl title, as the New England Patriots and the Pittsburgh Steelers are tied for the most SB wins (6). The San Francisco 49ers and the Dallas Cowboys follow them with five championships each, while the Green Bay Packers, the New York Giants, and the Kansas City Chiefs have won three titles each.
Here is how the last five Super Bowls finished:
| AFC East Participants | AFC East Division Winner Odds | Division Finish Prediction |
|---|---|---|
| Buffalo Bills* | 1.30 (3/10) | 1st |
| Miami Dolphins* | 8.0 (7/1) | 2nd |
| New England Patriots | 6.0 (5/1) | 3rd |
| New York Jets | 19.0 (18/1) | 4th |
The Buffalo Bills won the AFC East Division in five consecutive seasons, and it doesn’t look like they are stopping anytime soon. The Miami Dolphins should be back this season, with Tua Tagovailoa in top form again and Tyreek Hill and Jaylen Waddle’s high-quality duo as the top wide receivers. The New England Patriots finished with a 4-13 record in back-to-back seasons, while the New York Jets will rely on their new quarterback, Justin Fields, but they will most likely struggle again in the division.
| AFC North Participants | AFC North Division Winner Odds | Division Finish Prediction |
|---|---|---|
| Baltimore Ravens* | 1.60 (3/5) | 1st |
| Cincinnati Bengals* | 3.50 (5/2) | 2nd |
| Pittsburgh Steelers | 6.50 (11/2) | 3rd |
| Cleveland Browns | 31.0 (30/1) | 4th |
The Baltimore Ravens and the Cincinnati Bengals each won two AFC North Division titles in the last four years. The Ravens should thrive this regular season once again with the amount of stars they have, even though they got knocked out early in last season’s playoffs. The Pittsburgh Steelers’ hopes will be on Aaron Rodgers to deliver as their new quarterback, but he has to stay healthy throughout the season for them to make a playoff push. The Cleveland Browns were tied for the worst record in the league last season, and they haven’t improved much either.
| AFC South Participants | AFC South Division Winner Odds | Division Finish Prediction |
|---|---|---|
| Houston Texans* | 2.0 (Evs) | 1st |
| Jacksonville Jaguars | 4.0 (3/1) | 2nd |
| Indianapolis Colts | 4.75 (15/4) | 3rd |
| Tennessee Titans | 9.0 (8/1) | 4th |
C.J. Stroud is the best quarterback in this division, and he has enough offensive weapons to win the AFC South again this season. The Jacksonville Jaguars will be an interesting team to watch after they drafted Travis Hunter as the No. 2 pick in the draft. The Indianapolis Colts still have a dilemma in the quarterback position, but they will fight for one of the top two spots in the division. The Tennessee Titans have been struggling in the last few seasons, and they will most likely be at the bottom of the AFC South once again.
| AFC West Participants | AFC West Division Winner Odds | Division Finish Prediction |
|---|---|---|
| Kansas City Chiefs* | 1.90 (9/10) | 1st |
| Los Angeles Chargers* | 4.0 (3/1) | 2nd |
| Denver Broncos | 3.70 (27/10) | 3rd |
| Las Vegas Raiders | 17.0 (16/1) | 4th |
This is definitely one of the toughest divisions in the league. The Kansas City Chiefs had the best record in the AFC Conference last season, and they certainly won’t slow down with Patrick Mahomes at the wheel. The Los Angeles Chargers can have a great season if they can keep Justin Herbert healthy, while the Denver Broncos have a great defense and will challenge the Chargers for that second place. The Las Vegas Raiders lost all six of their division games last season, and they are expected to land the bottom spot this season again.
| NFC East Participants | NFC East Division Winner Odds | Division Finish Prediction |
|---|---|---|
| Philadelphia Eagles* | 1.66 (2/3) | 1st |
| Washington Commanders* | 3.10 (21/10) | 2nd |
| Dallas Cowboys | 8.0 (7/1) | 3rd |
| New York Giants | 23.0 (22/1) | 4th |
The Philadelphia Eagles are big favorites to win the division once again for obvious reasons. They are the Super Bowl defending champions, and they have kept most of their league-winning roster, so there’s not much to doubt about Philadelphia this season. Despite losing all their pre-season games, the Washington Commanders are still expected to do well, especially after reaching the NFC Championship Game last season. The Dallas Cowboys are heading in the wrong direction after losing Micah Parsons, while the New York Giants will most likely finish at the bottom once again.
| NFC Noth Participants | NFC North Division Winner Odds | Division Finish Prediction |
|---|---|---|
| Detroit Lions* | 3.0 (2/1) | 1st |
| Green Bay Packers* | 2.75 (7/4) | 2nd |
| Chicago Bears | 6.50 (11/2) | 3rd |
| Minnesota Vikings | 4.25 (13/4) | 4th |
The Detroit Lions won back-to-back NFC North titles for the first time in their history, and they should win the three-peat if they keep their great form. The Green Bay Packers’ future is bright with Jordan Love as their starting quarterback. The Chicago Bears finished last season at the bottom of the division with only five wins, but they should improve this season, while the Minnesota Vikings overperformed last season and are due for a regression.
| NFC South Participants | NFC South Division Winner Odds | Division Finish Prediction |
|---|---|---|
| Tampa Bay Buccaneers* | 2.0 (Evs) | 1st |
| Atlanta Falcons | 3.10 (21/10) | 2nd |
| Carolina Panthers | 5.0 (4/1) | 3rd |
| New Orleans Saints | 13.0 (12/1) | 4th |
The Tampa Bay Buccaneers have one of the best offenses in the league, and they should improve even more this season, which will boost their chances to go deep in the playoffs. The Atlanta Falcons have a lot of key players injured right now, and they could push for a playoff spot if they improve their passing game this season. The Carolina Panthers and the New Orleans Saints couldn’t win more than five games last season, and they haven’t done anything to prove this year will be different.
| NFC West Participants | NFC West Division Winner Odds | Division Finish Prediction |
|---|---|---|
| Los Angeles Rams* | 2.80 (9/5) | 1st |
| San Francisco 49ers* | 2.60 (8/5) | 2nd |
| Seattle Seahawks | 6.50 (11/2) | 3rd |
| Arizona Cardinals | 5.25 (17/4) | 4th |
The Los Angeles Rams signed Davante Adams in a big deal this offseason, and he should form a great duo with Matthew Stafford this season. The San Francisco 49ers are coming off a disappointing year, as they finished last in the NFC West Division last season after reaching the 2023 Super Bowl, but they will improve this time. It will be interesting to see how good this Seattle Seahawks offense will be with Cooper Kupp as their top wide receiver. The Arizona Cardinals could finish higher if they improve the defense and Kyler Murray gets back to his form.
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The Buffalo Bills have some exciting odds on the popular NFL bookies, as they are clearly much better this season and should improve on their AFC Championship Game loss from last season. The addition of Joey Bosa to this defensive line will be huge, especially since the Bills have been struggling defensively lately. Most of their draft picks were on the defense, so it’s good that they acknowledged their weakness and made big moves to solve it.
Josh Allen is the reigning MVP and is one of the best quarterbacks in the league, while Khalil Shakir has stepped up lately, and James Cook was tied for the most rushing touchdowns last season, so the Bills will give it another go to win the title.
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The Houston Texans have a great pass defense, with players like Danielle Hunter and Will Anderson Jr. They also have by far the best quarterback in the division, C.J. Stroud. Nico Collins and Christian Kirk are two impressive wide receivers, while Nick Chubb is also a top running back, so they should dominate the division once again if they keep their good form. The Texans had more wins than the Jacksonville Jaguars and the Tennessee Titans combined last season, while the Indianapolis Colts are inconsistent.
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The NFL 2025 divisional winner odds for the Los Angeles Rams have a lot of value. They have one of the best wide receiver duos in the league, Puka Nacua and Davante Adams, and they will have a huge boost with Matthew Stafford being healthy again and ready to play. The Rams had a weaker roster last season and still won the NFC West Division title. Sean McVay is the best coach in the division, and they have the potential to be Super Bowl contenders again.
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The NCAA football sportsbooks also follow the NFL and have some enticing odds on Christian McCaffrey to win the Comeback Player of the Year Award. McCaffrey was a monster before getting injured last season. He had seven receiving touchdowns and 14 rushing touchdowns in the 23/24 NFL season, leading the San Francisco 49ers to a Super Bowl appearance. McCaffrey always takes a lot of rushing attempts in every single game, and he will be one of the key players to get the 49ers back on track after a disappointing last season.
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Derrick Henry’s move to the Baltimore Ravens was one of the biggest moves last season, and he has signed a two-year extension with the team this off-season. Henry was tied for the most rushing touchdowns last season (16). He finished on top of the rushing touchdowns list in three of the last six seasons, and he is playing for the favorites to win the title, which boosts his chances of scoring a lot of touchdowns this season again.
This could finally be the Buffalo Bills’ year after their big adjustments in the off-season, and we expect them to win the title. Make sure to use our 2025 NFL season predictions and bet them at the best American football sportsbooks to have more fun watching the event.
