The Derby della Capitale is one of Serie A’s most intense rivalries, and AS Roma faces Maurizio Sarri’s Lazio in the league this weekend. It’s still early in 2025/26, but this clash is far more important than three points, and you sure don’t want to miss it. Our betting preview and predictions take a look at the state of both teams and what to expect from the Lazio vs Roma clash.
Gameweek 4 in the Italian Serie A sees Roma and Lazio square off at the Stadio Olimpico on Sunday, and the Giallarossi have a three-point lead over their city rivals.
| ℹ️ Tournament: | Italian Serie A season 2025-26, Matchday 4 |
| ⚽️ Venue: | Stadio Olimpico, Rome, Italy |
| 🗓️ Date: | 21 September 2025 |
| ⏰ Time: | 11:30 GMT on Sunday |
The odds on Serie A for the upcoming matchday are out, and it’s really tight between these teams, with the Giallarossi having a slight advantage at 2.62 (13/8). A draw has the biggest value on Lazio vs Roma odds, while Sarri’s team is backed at 2.80 (9/5) to win.
Roma hasn’t lost a league derby to Lazio since 2023—the only win for the Biancocelesti in that period came in the Coppa Italia. It’s been three derbies without a win now for Maurizio Sarri’s side, and they will be eying all three points here.
Sitting 12th after three matches, Lazio need a good result here after starting their league campaign with two defeats from three games. The Biancocelesti have won once this season in a 4-0 victory at home to Hellas Verona, but they haven’t been quite convincing against better opposition. They aren’t at their best for the derby, but they have enough quality to beat Roma, and the pressure is more on Lazio in this fixture.
Midfield veteran Matias Vecino is doubtful for this clash, and Lazio will be hoping he gets the medical clearance ahead of the derby. Samuel Gigot and Manuel Lazzari are injured and will miss the derby.
Roma lost their first game of the season, ending their spectacular unbeaten run in a 1-0 defeat to Torino. The Giallarossi are sixth on the log with two wins already, and they sit three points behind league leaders. AS Roma outplayed Torino despite the defeat, and they have already beaten the likes of Bologna this term. Confidence is high for the Giallarossi, who have got better results in the last derbies, and they will be looking to return to winning ways.
Due to a muscle injury, Leon Bailey is yet to make his official debut this season after joining Roma on loan from Aston Villa. Paulo Dybala was taken off against Torino and is expected to be back next month.
The Derby della Capitale is a special game, and there are some great betting opportunities for punters. Below are our Lazio vs Roma betting tips:
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Roma have been one of the best Italian teams this year, and after a poor start last season, they had a fantastic run in the second half of the campaign to earn themselves a European spot. In the last 23 Serie A games, the Giallarossi have lost only twice, and even the big teams can’t boast of a better record. Roma were able to win away at a compact Bologna team a few weeks ago, and they should have it easier here. Lazio have lost two of their last three matches, with their latest defeat coming against Sassuolo, a game where they were second best. It’s all pointing towards another derby win for the Giallarossi, and the best bookies for Serie A can return you a nice profit with this punt.
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Lazio are far from convincing this season, having failed to trouble Sassuolo last week, creating just one big chance in 90 minutes. It’s not the first time this season when Maurizio Sarri’s side have struggled in attack, and they also fired blanks in the defeat to Como. Roma’s strength has been their backline, and they rarely concede chances to opponents. In three games this season, the Giallarossi have kept two clean sheets, conceding just once in 180 minutes. The derby is always tougher, but Roma has kept two clean sheets in the last three meetings. Backing the away team to keep a clean sheet is a high-value pick on Lazio vs Roma betting predictions.
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Roma had the upper hand in this tie, but Lazio aren’t going to bend easily, and we’d expect both teams to be very compact in the first half of the derby. Lazio was able to stay level at halftime in the defeats to Como and Sassuolo, and they can definitely hold Roma out for the first 45 minutes of the derby. Gasperini and his team are yet to win at half-time this season, with all three league matches ending in a draw at the break. The variety of online football odds for this game is huge, and this option offers good value as the last derby was also tied at halftime.
Gian Piero Gasperini is having a good start with Roma, but they need a statement win to mark themselves as title favorites. Get the best value on Lazio vs Roma betting picks by using our expert tips and predictions.
